Tanja Henzler

Director Liquid Formulation R&D at Merck KGaA

Tanja Henzler studied Biology in Tübingen and received her PhD in Virology at the Ruprechts Karls University Heidelberg. In 2002 she joined Merck in Darmstadt, Germany. Tanja Henzler has a focus in protein characterization and protein analytics. After evaluating new technologies for Merck Life Science she was coordinating an interdisciplinary and cross-divisional innovation project.

She is now leading the group Liquid Formulation within Life Science/Process Solutions focusing on protein stability and Controlled Release of Biomolecules.


Title: Viscosity and Aggregation - Challenges in Biomolecule Formulation

  • Aggregation prevention is still one of the most prominent questions in Biomolecule Formulation. High quality excipients can help to reduce the risk of failure during formulation development.
  • Subcutaneous injections are getting the preferred way of administration for Large Molecules. However, technical challenges like high viscosity as well as protein aggregation arise in highly concentrated protein formulations. Excipients can reduce protein-protein interactions and therefore reduce viscosity in highly concentrated protein formulations.